interstitial fluid vs extracellular fluid

Interstitial fluid vs extracellular fluid skin#
Interstitial fluid vs extracellular fluid free#

Its concentration and alkaline reserve are similar to those of blood. Its pH, which is rarely measured clinically, is slightly more acidic than the pH of blood. On average, the total protein is about 15 to 50 mg/dL, and the concentration of glucose is about two thirds the concentration of glucose in the patient's serum. The initial pressure of spinal fluid in a side-lying adult is about 100 to 180 mm of water.

Interstitial fluid vs extracellular fluid free#

The fluid is normally watery, clear, colorless, and almost entirely free of cells. PMID 24503053.FLOW OF CEREBROSPINAL FLUID THROUGH THE BRAIN AND SPINAL COLUMN Formation, circulation, and reabsorption of CSF 'Lymphatic function and responses in periodontal disease'. 'Structure and Distribution of an Unrecognized Interstitium in Human Tissues'. Sackey-Aboagye, Bridget Klavan, Heather Reidy, Jason Buonocore, Darren Miranda, Markus Kornacki, Susan Wayne, Michael (). Clinical Journal of the American Society of Nephrology. ^ a b c Zeisberg, M Kalluri, R (2015).'Changes in the myocardial interstitium and contribution to the progression of heart failure'. ^ a b c Eckhouse SR Spinale FG (2012).San Rafael, CA: Morgan & Claypool Life Sciences. In: Capillary Fluid Exchange: Regulation, Functions, and Pathology. ^ a b Scallan J Huxley VH Korthuis RJ (2010).'Interstitial fluid and lymph formation and transport: Physiological regulation and roles in inflammation and cancer'. ^ a b c d e f g h i Wiig, H Swartz, M.Bethesda, MD: American Physiological Society. The interstitium and microvascular exchange. In people with lung diseases, heart disease, cancer, kidney disease, immune disorders, and periodontal disease, the interstitial fluid and lymph system are sites where disease mechanisms may arise or develop.

Interstitial fluid vs extracellular fluid skin#

The amount of interstitial fluid varies from about 50% of the tissue weight in skin to about 10% in skeletal muscle. The total fluid volume of the interstitium during health is about 20% of body weight, but this space is dynamic and may change in volume and composition during immune responses and in conditions such as cancer, and specifically within the interstitium of tumors. The composition and chemical properties of the interstitial fluid vary among organs and undergo changes in chemical composition during normal function, as well as during body growth, conditions of inflammation, and development of diseases, as in heart failure and chronic kidney disease. The interstitial fluid is a reservoir and transportation system for nutrients and solutes distributing among organs, cells, and capillaries, for signaling molecules communicating between cells, and for antigens and cytokines participating in immune regulation. The fluid spaces communicate with draining lymph nodes though they do not have lining cells or structures of lymphatic channels. The interstitium in the submucosae of visceral organs, the dermis, superficial fascia, and perivascular adventitia are fluid-filled spaces supported by a collagen bundle lattice. Such structural components exist both for the general interstitium of the body, and within individual organs, such as the myocardial interstitium of the heart, the renal interstitium of the kidney, and the pulmonary interstitium of the lung. The non-fluid parts of the interstitium are predominantly collagen types I, III, and V, elastin, and glycosaminoglycans, such as hyaluronan and proteoglycans that are cross-linked to form a honeycomb-like reticulum. The interstitial compartment is composed of connective and supporting tissues within the body – called the extracellular matrix – that are situated outside the blood and lymphatic vessels and the parenchyma of organs. The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph system.

The interstitium is a contiguous fluid-filled space existing between a structural barrier, such as a cell membrane or the skin, and internal structures, such as organs, including muscles and the circulatory system.